Ask Eolas Eliminates Antibiotic Prescribing Errors in Nature Study

Written by

Ask Eolas Achieved 100% Prescribing Accuracy in a Nature-Published Randomized Controlled Trial

Cambridge, United States – April 21, 2026 / Eolas Medical /

CAMBRIDGE, MA, April 21, 2026 — A peer-reviewed study published in npj Antimicrobials and Resistance has demonstrated that Ask Eolas, an AI-powered clinical decision support system developed by Eolas Medical, achieved 100% prescribing accuracy in a randomized controlled study conducted by researchers at Imperial College London, with support from the NIHR Northwest London Patient Safety Research Collaboration.

The U.S. Antibiotic Crisis

American hospitals face mounting pressure to reduce inappropriate antibiotic use under stewardship mandates from The Joint Commission, CMS, and the CDC’s National Action Plan for Combating Antibiotic-Resistant Bacteria. According to the CDC, up to 50% of antibiotics prescribed in U.S. hospitals are unnecessary or inappropriately prescribed, contributing to more than 2.8 million antibiotic-resistant infections and over 35,000 deaths annually.

Study Design and Key Findings

The study evaluated three tools across progressively complex prescribing scenarios involving 45 clinicians: Hospital PDF Guidelines (47%), the Eolas App (60%), and Ask Eolas (100%). The improvement was statistically significant (p < 0.001). The absolute risk reduction was 53% compared to standard PDF guidelines, with a number needed to treat (NNT) of 1.9 — meaning for every two clinicians using Ask Eolas, one additional prescribing error was prevented.

Boosting Clinician Confidence and Reducing Cognitive Load

Clinicians using Ask Eolas also reported substantially higher prescribing confidence and lower cognitive workload across all NASA Task Load Index (a standardized cognitive workload assessment) domains.

Ask Eolas Technology

With Ask Eolas, clinicians ask a question in natural language and receive an answer drawn exclusively from their health system’s own approved guidelines and protocols, with full source references — improving clinician access and adherence to hospital-developed and approved protocols and guidelines at the point of care.

U.S. Expansion and Deployment

Eolas Medical is already deployed across several leading U.S. health systems and academic medical centers including Mass General Brigham, Stanford, and Boston Children’s Hospital, and is expanding antimicrobial stewardship capabilities nationwide.

The company recently opened its U.S. headquarters in Cambridge, Massachusetts, and continues to build out its team to expand its reach across the U.S. market.

“This study demonstrates how guideline-grounded AI can strengthen antimicrobial stewardship infrastructure while supporting frontline clinicians in high-pressure environments. With the opening of our U.S. headquarters in Cambridge, Massachusetts, we are firmly committed to making this technology available to health systems across the country, because every clinician deserves real-time access to the best evidence at the point of care,” said Dr. Declan Kelly, Founder & CEO of Eolas Medical.

About Eolas Medical

Eolas Medical is a healthcare knowledge management platform used by clinical teams across the United States, United Kingdom and Ireland to improve access to trusted treatment guidance at the point of care. Its software helps hospitals strengthen antimicrobial stewardship programs, reduce prescribing variation and support safer frontline decision-making.

Ask Eolas, the company’s AI clinical decision support capability, uses retrieval-augmented generation to deliver recommendations grounded exclusively in hospital-approved clinical guidelines, enabling transparent, auditable and institution-aligned prescribing support.

Eolas Medical is deployed across leading U.S. health systems and academic medical centers and continues to expand its role in supporting stewardship, patient safety and clinical workflow optimization nationwide.

Learn more at www.eolasmedical.com.

Read the full study here.

Media Contact

Laura Kleffner, Head of Marketing

Eolas Medical

laura.kleffner@eolasmedical.com